Niacinamide: The Ingredient That Does It All

By Dr. Rachel Foster · October 12, 2026

What Is Niacinamide?

Niacinamide is a form of vitamin B3 that your body can't produce on its own. Applied topically, it's one of the most versatile and well-researched skincare ingredients available. Unlike retinol or vitamin C, it's gentle enough for virtually every skin type.

What It Does (Evidence-Backed)

Minimizes Pores

Niacinamide regulates sebum production and strengthens the pore lining, making pores appear smaller. A 2006 study showed visible pore reduction within 4 weeks of 2% niacinamide use.

Reduces Hyperpigmentation

It blocks the transfer of melanin to skin cells (unlike hydroquinone which blocks production). This makes it effective for dark spots without the risk of ochronosis.

Strengthens the Skin Barrier

Niacinamide boosts ceramide production, which is essential for a healthy moisture barrier. This makes it ideal for sensitive, dry, or compromised skin.

Fights Inflammation

Its anti-inflammatory properties help with acne, rosacea, and general redness. Studies show it's comparable to clindamycin for mild-to-moderate acne.

Concentration Guide

2-5%: Effective for most concerns, minimal irritation risk
10%: Stronger results but may cause flushing in sensitive skin
15-20%: Excessive for most people, increased irritation risk

How to Use

Apply a niacinamide serum after cleansing and toning, before moisturizer. It pairs well with virtually every other ingredient — retinol, vitamin C, AHAs, peptides. Despite old myths, niacinamide and vitamin C can absolutely be used together.